Adam V Wisnewski Selected Research

4,4'-diphenylmethane diisocyanate (methylene diphenyl diisocyanate)

1/2022	Severe asthma and death in a worker using methylene diphenyl diisocyanate MDI asthma death.
1/2020	Analysis of Lung Gene Expression Reveals a Role for Cl- Channels in Diisocyanate-induced Airway Eosinophilia in a Mouse Model of Asthma Pathology.
3/2019	LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.
1/2019	Dilysine-Methylene Diphenyl Diisocyanate (MDI), a Urine Biomarker of MDI Exposure?
11/2016	The influence of diisocyanate antigen preparation methodology on monoclonal and serum antibody recognition.
4/2015	Glutathione reaction products with a chemical allergen, methylene-diphenyl diisocyanate, stimulate alternative macrophage activation and eosinophilic airway inflammation.
9/2013	Connecting glutathione with immune responses to occupational methylene diphenyl diisocyanate exposure.
6/2013	Molecular determinants of humoral immune specificity for the occupational allergen, methylene diphenyl diisocyanate.
3/2011	Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responses.
5/2010	Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate.

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Adam V Wisnewski Research Topics

Disease

18	Asthma (Bronchial Asthma) 01/2022 - 05/2002
13	Occupational Asthma 01/2022 - 09/2003
6	COVID-19 01/2022 - 12/2020
4	Infections 01/2022 - 01/2021
4	Inflammation (Inflammations) 04/2015 - 05/2002
3	Eosinophilia 01/2020 - 05/2002
2	Disease Progression 01/2021 - 12/2020
1	Occupational Diseases (Occupational Disease) 01/2019
1	Neoplasms (Cancer) 05/2017
1	Hematologic Neoplasms (Hematological Malignancy) 05/2017
1	Hypersensitivity (Allergy) 10/2011
1	Long Term Adverse Effects 05/2003
1	Pneumonia (Pneumonitis) 05/2002

Drug/Important Bio-Agent (IBA)

10	4,4'-diphenylmethane diisocyanate (methylene diphenyl diisocyanate)IBA 01/2022 - 05/2010
8	Immunoglobulin G (IgG)IBA 01/2021 - 04/2007
7	Polyurethanes (Polyurethane)IBA 06/2020 - 04/2007
6	IsocyanatesIBA 04/2015 - 09/2003
5	AntigensIBA 01/2021 - 05/2002
5	Immunoglobulin E (IgE)IBA 01/2020 - 10/2006
3	EnzymesIBA 01/2022 - 04/2007
3	VaccinesIBA 01/2022 - 01/2021
3	AllergensIBA 01/2022 - 03/2013
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 05/2003
3	1,6-hexamethylene diisocyanate (hexamethylene diisocyanate)IBA 01/2018 - 05/2003
3	Glutathione (Reduced Glutathione)IBA 04/2015 - 10/2011
3	Toluene 2,4-Diisocyanate (Toluene Diisocyanate)IBA 02/2012 - 10/2006
3	AlbuminsIBA 03/2011 - 06/2004
2	SARS-CoV-2 spike proteinIBA 01/2022 - 01/2021
2	Neutralizing AntibodiesIBA 07/2021 - 01/2021
2	mRNA VaccinesIBA 01/2021 - 01/2021
2	Antiviral Agents (Antivirals)IBA 01/2021 - 12/2020
2	Proteins (Proteins, Gene)FDA Link 05/2018 - 05/2010
2	2- n- butyl- 3- (dimethylamino)- 5,6- methylenedioxyindeneIBA 06/2013 - 03/2011
1	Angiotensin-Converting Enzyme 2IBA 01/2022
1	Messenger RNA (mRNA)IBA 01/2021
1	Immunoglobulin A (IgA)IBA 01/2021
1	EpitopesIBA 01/2021
1	ChemokinesIBA 01/2020
1	Biological ProductsIBA 01/2020
1	Peptides (Polypeptides)IBA 05/2018
1	Alkylating AgentsIBA 05/2017
1	laromustine (VNP40101M)IBA 05/2017
1	DNCOIBA 11/2016
1	Elastomers (Elastomer)IBA 06/2013
1	polyurethane foamIBA 06/2013
1	TolueneIBA 04/2007
1	diphenylmethaneIBA 04/2007
1	ImmunosorbentsIBA 04/2007
1	Carrier Proteins (Binding Protein)IBA 10/2006
1	Sulfhydryl Compounds (Thiols)IBA 05/2003
1	Glutathione Transferase (Glutathione S-Transferase)IBA 05/2003
1	CytokinesIBA 05/2002

Therapy/Procedure

1	Therapeutics 01/2021
1	Personal Protective Equipment 10/2012
1	Mechanical Ventilators (Ventilator) 10/2012